The time hierarchy theorem is the subject of my diploma project, perhaps you want to view the comments on my question Lower bounds and class separation .
Looking back to this question and how it relates to what you are asking, I got an idea that might show that the multitape to single tape TM simulation overhead needed by the theorem's proof cannot be improved. Thus, another approach is needed if we wish to improve this result.
EDIT: This proof is incorrect, see the comments below for the exact reason. I am currently editing the answer to reflect that.
Let A be the language {0k1k|k≥0} .
On a single tape machine, there is an O(nlogn) algorithm (you can find details of this algorithm in chapter 7.1.2 of Sipser's book "Introduction to the Theory of Computation). In the same reference, you can see that a language is in o(n \log n) if and only if it is regular. Kaveh also provides the original papers for this claim in the question linked above.
In the comments of my question, Ryan Williams illustrates an O(n) algorithm for the same problem, using a 2-tape TM.
Assume now that there is a technique for simulating a multitape TM into a single tape TM that has a running time of o(T(n)logT(n)), where T(n) is the running time of the TM simulated. By applying it to the machine Ryan illustrates, we would get a single tape TM that would run in o(nlogn). Therefore, A is regular , which is a contradiction. So, we conclude that an overhead of logT(n) is the best we can do when simulating multi tape machines with single tape machines.
Zdaję sobie sprawę, że to mocne stwierdzenie, więc mogę się mylić w mojej interpretacji.
NTIME or SPACE. My intuition derives by the following fact:
There is a very known result that states DTIME(n)≠NTIME(n). Under the assumption that P≠NP I believe this result is improved to DTIME(nk)≠NTIME(n) , for any k.So, a very small non-deterministic class is much more powerful than any deterministic. So, given how powerful a resource non-deterministic time is, I would expect that a greater amount of deterministic time would be needed to make a TM more powerful to compensate for non-determinism's power.